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Shares of Glenmark, traded on the Bombay Stock Exchange, initially surged more than 20% on news of the deal, which is unusual in that it involves a biologic drug candidate

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with an $8.9 billion loss a year earlier when the company swallowed a big writedown of the IT outsourcing

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If the enzyme is inhibited because of the concurrent use of medications, it is unavailable to metabolize the anesthetic and potentially toxic levels of the anesthetic can occur